Potential Role of Mitogen-Activated Protein Kinase during Meiosis Resumption in Bovine Oocytes1
نویسندگان
چکیده
منابع مشابه
Regulation of mitogen-activated protein kinase 3/1 activity during meiosis resumption in mammals
In vivo, resumption of oocyte meiosis occurs in large ovarian follicles after the preovulatory surge of luteinizing hormone (LH). The LH surge leads to the activation of a broad signaling network in mural granulosa cells equipped with LH receptors. The signals generated in the mural granulosa cells are further augmented by locally produced peptides or steroids and transferred to the cumulus cel...
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The requirement of mitogen-activated protein kinase (MAPK) for the initiation of meiotic maturation in porcine oocytes was examined using U0126, an inhibitor of MAPK activator. Immunoblot analysis and kinase assay showed that U0126 inhibited the phosphorylation and activation of MAPK incompletely in porcine oocytes. In this condition, maturation/M-phase promoting factor (MPF) activity was also ...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1996
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod55.6.1261